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Baker Institute |  Faculty



Doug Antczak, VMD, PhD
Dorothy Havemeyer McConville Professor of Equine Medicine

Equine Genetics Center

A day 33 horse conceptus, showing the principal components of the developing placenta. The invasive band of cells of the chorionic girdle are poised to migrate into the uterus at day 36-38 to establish the dramatic structures of the endometrial cups. The cup cells are the sole source of equine chorionic gonadotropin, and they also provide a strong immunological stimulus to the mare at this critical stage of equine pregnancy.

A day 33 horse conceptus, showing the principal components of the developing placenta. The invasive band of cells of the chorionic girdle are poised to migrate into the uterus at day 36-38 to establish the dramatic structures of the endometrial cups. The cup cells are the sole source of equine chorionic gonadotropin, and they also provide a strong immunological stimulus to the mare at this critical stage of equine pregnancy.

For 20 years our program has focused on the biological interactions that take place between a mother and fetus during pregnancy. In particular, we are concerned with how the placenta and fetus avoid recognition and destruction by the maternal immune system. This is an intriguing question that has broad applications to many areas of biology and medicine, including organ transplantation and cancer biology.

In the course of these studies our laboratory has acquired expertise in three important areas of equine medicine: immunology, genetics, and reproduction. The immunological assays we have developed for our research are also used to characterize immune system defects in horses admitted to the Large Animal Hospital at Cornell. Our reproductive studies have led to new ways to study the growth and function of the placenta. Finally, our genetic studies have been fundamental to the international collaboration of the Horse Genome Project.

Because of the laboratory resources that we have developed here at the Baker Institute, we are in a unique position to investigate the complex interactions between mother and fetus. Our studies are of relevance not only to horses, but to other animals and to human health.


Doug Antczak

Contact Information:
Office: 607-256-5633
Lab: 607-256-5621
Fax: 607-256-5608
E-mail: dfa1@cornell.edu

Emerging Infectious Diseases

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