Research on Lavender Foal Syndrome
Exciting research findings on Lavender Foal Syndrom have been published recently in the the journal PLoS Genetics. The project was a joint effort between Doug Antczak’s lab and that of Dr. Samantha Brooks of the Department of Animal Science. Dr. Brooks was the lead author on the study.
LFS is an important inherited disease of Arabian horses that causes a complex neurological condition that is always lethal shortly after birth. The disease is classified as an autosomal recessive condition. That means that horses carrying one copy of the mutant gene appear normal. Only horses that carry two copies of the mutant gene (one from each parent) are affected. Researchers in the laboratories of Dr. Brooks and Antczak have identified the mutated gene (myosin Va) that causes the disease and developed a simple molecular assay that can be used as a diagnostic test to determine carrier status.
This article is available through PubMed Open Access.
Brooks, S.A. et al. Whole-Genome SNP Association in the Horse: Identification of a Deletion in Myosin Va Responsible for Lavender Foal Syndrome. PLoS Genetics 6(4):e1000909.